Tuberculosis : Definition:
It is a chronic granulomatous infection caused by the bacterium mycobacterium tuberculae
Pathogenesis:
It is a chronic granulomatous infection caused mainly by the inhalation of tubercular bacilli. The bacilli enters the lungs and get deposited on the upper lobe of the lungs there it forms a primary complex. Once this complex is formed the disease spread through the lymphatic vessel to the adjacent organs or locally.
Drugs:
First line drugs: Isoniazid, Rifampicin, ethambutol and Pyrizanamide
Second line drugs: Aminoglycosides like Amikacin, kanamycin.
Polypeptides like capreomycin.
Fluoroquinolones like ciprofloxacin, levofloxacin, moxifloxacin
Thioamides like ethionamide, prothionamide
Cycloserine
Para aminosalicylic acid
Third line drugs : Rifabutin
Macrolides like clarythromycin
Linezolid
Thioacetazone
Vitamin D
Thioridazine
Tuberculosis : Definition:
It is a chronic granulomatous infection caused by the bacterium mycobacterium tuberculae
Pathogenesis:
It is a chronic granulomatous infection caused mainly by the inhalation of tubercular bacilli. The bacilli enters the lungs and get deposited on the upper lobe of the lungs there it forms a primary complex. Once this complex is formed the disease spread through the lymphatic vessel to the adjacent organs or locally.
Drugs:
First line drugs: Isoniazid, Rifampicin, ethambutol and Pyrizanamide
Second line drugs: Aminoglycosides like Amikacin, kanamycin.
Polypeptides like capreomycin.
Fluoroquinolones like ciprofloxacin, levofloxacin, moxifloxacin
Thioamides like ethionamide, prothionamide
Cycloserine
Para aminosalicylic acid
Third line drugs : Rifabutin
Macrolides like clarythromycin
Linezolid
Thioacetazone
Vitamin D
Thioridazine