brand name : DEVOT 500MG TABLET XL

Generic name : Divalproex

Basic Info

Use of Drug

Bipolar disorder

Epilepsy

Migraine

Headache

Category Of Drug

Anticonvulsants

Side Effects

Most Common- Nausea, vomiting, drowsiness, dizziness, weakness, abdominal pain, indigestion and rash. 

Body as a Whole- Chest pain, chills, fever, neck pain and neck rigidity. 

Heart- High/low blood pressure, fast heart rate and dilation of blood vessels. 

Gastrointestinal- Loss of appetite, fecal incontinence, flatulence, inflammation of gastrointestinal tract/tongue and mouth infection. 

Blood- Bruising. 

Metabolic - Swelling in the extremities and weight gain. 

Musculoskeletal- Joint pain, leg cramps and twitching. 

Central Nervous System- Abnormal dreams, abnormal gait, agitation, in-coordination, muscle rigidity, memory loss, sleeplessness, tingling, involuntary movements, abnormal thinking and fainting. 

Respiratory - Difficulty in breathing and inflammation of nose. 

Skin - Hair loss, skin scar, dry skin, boils, rash, itching and dandruff. 

Eye and ENT- Lazy eye, inflammation of eyes, dry eyes, double vision, deafness, ear/eye pain and ringing.

Drug Dose Information

Adult: 
PO Partial seizures; Primary generalised seizures:
Initial: 10-15 mg/kg/day in 2-4 divided doses. Max: 60 mg/kg/day. 

Acute manic episodes of bipolar disorder:
Initial: 25 mg/kg once daily. Max: 60 mg/kg/day. 

MIgraine prophylaxis :
500 mg once daily for 1 wk, up to 1,000 mg once daily.

Precautions

Children <2 yr
Congenital metabolic disorders
Organic brain disease or severe seizure disorders
HIV infection
Renal impairment
Lactation
Monitor liver function before and during the 1st 6 mth of therapy.
Monitor platelet function
Signs of pancreatitis and SLE
Gradual withdrawal of valproate
May impair ability to drive or operate machinery
Increased risk of hyperammonaemic encephalopathy in patients with urea cycle disorders.

Brand Information

Brand Name	DEVOT 500MG TABLET XL
Contains	Divalproex500 mg
Manufacturer Name	JB Chemicals & Pharmaceuticals Ltd

Brand Specifications
	Unit	Quantity	Price	Type
1	10's	1Strip	210.0000	Tablet

How To Take

It is available as a tablet taken orally, with food.

Storage

Oral: Store it at controlled room temperature (15-30°C).

Contra Indications

Hepatic disease or severe hepatic impairment Porphyria Pregnancy

Diseases

Gallstone : .

Biliary cirrhosis : .

Gallstone : .

Biliary cirrhosis : .

Felbamate increases valproate levels. Phenytoin, phenobarbitone and carbamazepine lower valproate levels. Increased risk of hepatotoxity with hepatotoxic drugs. Potentiates action of CNS depressants (barbiturates, primidone) and alcohol.

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drug’s Side effects

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brand name : DEVOT 500MG TABLET XL

Generic name : Divalproex

Basic Info

Use of Drug

Category Of Drug

Side Effects

Drug Dose Information

Precautions

Brand Information

How To Take

Storage

Contra Indications

Diseases

Interactions

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brand name : DEVOT 500MG TABLET XL

Generic name : Divalproex

Basic Info

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drug’s Side effects

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