Genexol-PM
PACLITAXEL
Lupin Limited
It available as a solution for injection to be administered by a healthcare provider into the vein.
Paclitaxel ; Belongs to the class of plant alkaloids and other natural products, taxanes. Used in the treatment of cancer.
Contraindicated in patients with extremely low white blood cell counts and hypersensitivity.
Hypotension (Low Blood Pressure) : Hypotension, also referred to as Low Blood Pressure. Low blood pressure occurs when blood pressure is much lower than normal. This means the heart, brain, and other parts of the body do not get enough blood. Normal blood pressure is usually between 90/60 mmHg and 130/80 mmHg. Certain medicines and substances can lead to low blood pressure, including: • Alcohol • Anti-anxiety medicines • Certain antidepressants • Diuretics • Heart medicines, including those used to treat high blood pressure and coronary heart disease • Medicines used for surgery • Painkillers Other causes of low blood pressure include: • Nerve damage from diabetes • Changes in heart rhythm (arrhythmias) • Not drinking enough fluids (dehydration) • Heart failure Symptoms Symptoms of low blood pressure may include: • Blurry vision • Confusion • Dizziness • Fainting (syncope) • Lightheadedness • Nausea or vomiting • Sleepiness • Weakness Treatment • Use more salt. • Drink more water. Fluids increase blood volume and help prevent dehydration, both of which are important in treating hypotension. • Wear compression stockings. The same elastic stockings commonly used to relieve the pain and swelling of varicose veins may help reduce the pooling of blood in your legs. • Medications. Several medications, either used alone or together, can be used to treat low blood pressure that occurs when you stand up (orthostatic hypotension). The drug fludrocortisone is often used to treat this form of low blood pressure.
Myelosuppression was more profound when given after cisplatin than with the alternate sequence. CYP2C8 inducers e.g. carbamazepine, phenobarbital, phenytoin, rifampicin, rifapentine, and secobarbital may reduce levels or effects. CYP2C8 inhibitors e.g. gemfibrozil, ketoconazole, montelukast, and ritonavir may increase levels or effects. CYP3A4 inducers e.g. aminoglutethimide, carbamazepine, nafcillin, nevirapine, phenobarbital, phenytoin, and rifamycins may decrease the levels or effects.
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It is any effect of a drug, chemical, or other medicine that is in addition to its intended effect, especially an effect that is harmful or unpleasant.